By Gustav K. von Schulthess, Christoph L. Zollikofer
This e-book represents a condensed model of the 20 issues facing imaging prognosis and interventional treatments in musculoskeletal ailments. The disease-oriented subject matters surround the entire appropriate imaging modalities together with X-rays expertise, nuclear drugs, ultrasound and magnetic resonance, in addition to image-guided interventional ideas.
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Extra resources for Musculoskeletal Cancer Surgery
Example text
44 There was also a significant decrease in the delivered dose of Adriamycin by the fourth cycle (from 60 to 51 mg/m2). Patients with low- to intermediate-grade tumors responded less frequently to MAID (18%) than to AD (29%). A univariate analysis demonstrated a significant survival advantage for the two-drug arm AD in patients greater than 50 years old and those with lowto intermediate-grade tumors. This advantage for AD has been hypothesized to be due to the lower dose intensity of Adriamycin in the three-drug arm and to the fact that patients who failed on the AD arm subsequently received ifosfamide, which provided a secondary benefit.
Curettage, burr drilling, and, in most cases, the use of adjuvant liquid nitrogen should be considered. Intermediate- and high-grade chondrosarcomas, on the other hand, are treated surgically by wide resection. The use of neoadjuvant and adjuvant chemotherapy for chondrosarcomas is controversial. Low- and intermediate-grade chondrosarcomas A 29 respond poorly to chemotherapy. Although there are few data on the efficacy of chemotherapy in the treatment of high-grade chondrosarcomas, it should be considered in any young patient with a high-grade tumor.
8. Frassica FJ, Frassica DA, Sim FH. Carcinoma metastatic to bone: pathogenesis and pathophysiology. In: Simon MA, Springfield D, editors. Surgery for Bone and Soft-Tissue Tumors. Philadelphia: Lippincott-Raven; 1998:615–20. 9. McKenna RJ, Schwinn CP, Soong KY, Higinbotham NL. Sarcomata of osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteosarcoma and sarcomata) arising in abnormal bone: an analysis of 552 cases. J Bone Joint Surg. 1966;48A:1–26. 10. Davies NM, Livesly PJ, Cannon SR.