By M. A. Hayat
With an annual expense of greater than 12 million international diagnoses and 7.6 million deaths, the societal and monetary burden of melanoma can't be overstated. mind metastases are the commonest malignant tumors of the important frightened process, but their prevalence seems to be expanding even with the development of melanoma cures. whereas a lot is understood approximately fundamental cancers (including fundamental mind tumors), much less paintings has been performed to discover the roots of metastatic disorder. This quantity fills that hole, serving because the first connection with concentration totally on the hyperlink among basic cancers and mind metastases. This hyperlink is explored for the commonest melanoma forms - lung, breast, and cancer. also, organic historical past in addition to treatment for CNS metastases is addressed. Age and gender comparable tendencies also are mentioned, as is using biomarkers for early detection.
*The merely accomplished reference detailing the hyperlink among fundamental cancers and mind metastases
*Aids the objective viewers in making a choice on the occurrence of mind metastases in sufferers with a first-rate cancer
*Provided schooling in regards to the capability use of biomarkers for early detection, analysis and prevention of the unfold of basic melanoma to the brain
*Documents temporal and gender-related traits in mind metastases from different cancers
*Edited paintings with chapters authored via leaders within the box around the world - the broadest, so much specialist assurance available
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Additional info for Brain Metastases from Primary Tumors. Epidemiology, Biology, and Therapy
2005). The interaction with metastatic tumor cells in the brain is largely based on the neoplastic angiogenesis/vascular remodeling as in other organs and on three other unique properties that differentiate the brain from other organs. 1. Angiogenesis/vascular remodeling: the potent angiogenesis/permeability factor, vascular endothelial growth factor (VEGF) plays a crucial role in the development of pathological neovascularization and in the increase of microvessel density. Whether tumor-associated blood vessels are formed by new vessel formation or by co-option of existing highly dense vessels is not yet clear.
C H A P T E R 3 Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases Chiara Calatozzolo, Emilio Ciusani, Elena Corsini, Francesco Di Meco, Bianca Pollo and Andrea Salmaggi O U T L I N E Introduction 25 CXCL12 and its Receptors 26 CXCL12 Axis in Brain 28 Brain Metastasis and CXCL12/CXCR4/CXCR7 31 Conclusions 33 References 34 CXCL12/CXCR4/CXCR7 and Metastasis 28 INTRODUCTION Chemokines are a superfamily of small cytokines (8–12 kDa) with chemotactic properties. They bind to specific receptors and are involved in cell trafficking, activation and differentiation.
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