By R. Dulbecco (auth.), Prof. Dr. A. Cittadini, Prof. Dr. R. Baserga, Prof. Dr. H. M. Pinedo, Prof. Dr. T. Galeotti, Dr. D. Corda (eds.)
The uncomplicated wisdom of cellphone biology and molecular genetics in oncology is more and more attracting the curiosity of medical oncologists and is with regards to achieving a necessary software on the bedside. at this time, it sort of feels transparent that the answer of the melanoma challenge lies in the comprehension of the intimate mechanisms resulting in telephone transformation and tumor development as weIl as of the cancer-host courting. in line with this reason each fulfillment during this context may perhaps enormously increase either analysis and remedy of neoplastic illnesses. This={)ook represents the lawsuits of the overseas convention o~ melanoma: organic Mechanisms and scientific purposes, held in Rome on November 16-18, 1992. The assembly used to be prepared via the Centro di Ricerche Oncologiche "Giovanni XXIII" of the Catholic collage of Rome and the Consorzio Mario Negri Sud of S. M. Imbaro in collaboration with different colleagues from the schools of Napoli and Bologna. As organizers and pmticipants to the convention we predict the assembly was once successful, as was once proven by means of the good curiosity raised in clinical and educational circles. The e-book collects contributions from best scientists in all oncological m·eas starting from molecular biology to immunology, prognosis and remedy. The papers are geared up into 4 sections: I - Molecular features of cellphone transformation and development; II - Membrane receptors and sign transduction; III - versions for brand new therapeutical ideas; IV - medical purposes, following the tactic that chm·acterized the full assembly: from molecule to bedside.
Read or Download Molecular Oncology and Clinical Applications PDF
Best oncology books
Energy Balance and Gastrointestinal Cancer
The gastrointestinal song presents one of many unique platforms the place a number of malignancies, together with adenocarcinoma of the pancreas, esophagus and colon are each one linked to weight problems. This particular organization is roofed during this quantity of power stability and melanoma from the epidemiologic, biologic and capability etiologic standpoint.
Brain Metastases from Primary Tumors. Epidemiology, Biology, and Therapy
With an annual price of greater than 12 million international diagnoses and seven. 6 million deaths, the societal and financial burden of melanoma can't be overstated. mind metastases are the commonest malignant tumors of the significant apprehensive procedure, but their occurrence seems to be expanding regardless of the development of melanoma cures.
Branching Process Models of Cancer
This quantity develops effects on non-stop time branching procedures and applies them to review fee of tumor progress, extending vintage paintings at the Luria-Delbruck distribution. as a result, the writer calculate the likelihood that mutations that confer resistance to therapy are current at detection and quantify the level of tumor heterogeneity.
- The Gale Encyclopedia of Cancer (Two Volume Set)
- Cancer Sourcebook for Women, 4th edition (Health Reference Series)
- Hematopathology in Oncology (Cancer Treatment and Research)
- Microscopic Scale of Cancer Systems Biology
Extra resources for Molecular Oncology and Clinical Applications
Sample text
These authors demonstrated that, of the various growth factors, needed for the growth in size of 3T3 cells, IGF-l was by far the most potent, accounting, in fact, for almost an the activity of serum. Also very clear is the role of IGF-l in the stimulation of DNA synthesis (which, for practical purposes, is almost synonymous with chromosomal replication). A copious literature is available on this point, literature which is centered on the "competence-progression theory" (Scher et al. 1979, Stiles et al.
These findings are of obvious relevance to the interpretation of human mixed cancer families as they suggest differential expression of a single pleiotropic mutation in the etiology of clinically-associated cancers of different histological types, perhaps augmented by differing progressional events (Figure 2). Table 11. Loss of heterozygosity for loci on chromosome 13q in osteosarcomas Alleles Present at Locus Patient Tissue* 013S1 013S7 013S4 013S5 013S3 Mechanism Osteo03 N T 1,2t 2,2 1,1 1,1 2,2 2,2 -t 1,2 1,1 Isodisomy Osteo06 N T 1,2 1,1 1,1 1,1 1,1 1,1 1,2 1,1 1,1 1,1 Isodisomy Osteo 09 N T 2,2 2,2 1,1 1,1 2,2 2,2 2,2 2,2 1,2 1,1 Isodisomy A.
1992). Antisense experiments, and experiments with IGF-l peptide analogs (see below) confirm the absolute requirement for IGF-l for the induction of DNA synthesis in many cell types in culture and in vivo. , 1988). An important question at this point is: why IGF-l, in some cases, induces only growth in size, while, in other cases (association with other growth factors) it is mitogenic? As mentioned above, the fact that PDGF and EGF increase the number of IGF-l binding sites would tempt us to explain the difference purelyon the basis of the number of IGF-l receptors.