By Faris Farassati
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However, their effectiveness in combination with other targeted therapeutics should form the next stage of their development as a therapeutic target. 8. References Abounader, R. and J. Laterra (2005). Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol, Vol. 7, No. 4, (Oct) pp. 436-451. , et al. (2006). Long term responses with cetuximab therapy in glioblastoma multiforme. Cancer Biol Ther, Vol. 5, No. 8, (Aug) pp. 912-914. , et al. (2009). Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.
537-543. , et al. (2006). Gefitinib accumulation in glioblastoma tissue. Cancer Biol Ther, Vol. 5, No. 5, (May) pp. 483-484. 38 Novel Therapeutic Concepts in Targeting Glioma Huang, H. , et al. (1997). The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem, Vol. 272, No. 5, (Jan 31) pp. 2927-2935. Inda, M. , et al. (2010). Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.
Qui\ nones-Hinojosa A. Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer agents in medicinal chemistry. 2010;10(2):121. [61] Benedetti S, Pirola B, Pollo B, et al. Gene therapy of experimental brain tumors using neural progenitor cells. Nat. Med. 2000;6(4):447-450. [62] Barresi V, Belluardo N, Sipione S, et al. Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy. Cancer Gene Ther. 2003;10(5):396-402. 24 Novel Therapeutic Concepts in Targeting Glioma [63] Tang Y, Shah K, Messerli SM, et al.