By George M. Hahn
Hyperthermia as a device for the remedy of malignant affliction is swiftly turning into a medical truth. during this publication i'm trying to summarize the identified organic and actual underpinnings that experience resulted in this improvement. I additionally current a compilation of latest medical effects, restricted as those are. My goal is to supply oncologists and different physicians with updated info in this modality, that's either new and previous, in addition to to make on hand to biologists, physicists and engineers sum maries of at present to be had details on particular parts of hyperthermic examine. many folks have helped me with this publication. in particular, thank you are because of Drs. William Dewey, Jean Dutreix, Peter Fessenden, Gloria Li, and Jane Marmor. Their feedback were priceless. i'm hoping that no longer too many blunders and omissions have crept into the quantity, yet at the least, for those i've got in basic terms myself guilty. I additionally desire to show my appreciation to David Betten and Marie Graham for his or her support. so much of this fabric was once written whereas i used to be on sabbatical go away at the seashores of Lake Atitlan in Guatemala. There I loved the hospitality of a gracious, pleasant, and proud those who deserve higher than destiny turns out to have in shop for them.
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The effect of nutrient environment on cell survival. HA-l cells in the plateau phase of growth were heated in media supplemented with the indicated percentage of fetal bovine serum. Closed circles: 43°. 2 hr; open circles: 43°. 3 hr. The correlation between survival and serum concentrations reflects changes in the environment during heating. Data from Hahn (1974). with permission. '" C :~ 2: :::J (/) 10·2'--_'______- L_ _ _ _ _ _- I - - I o 5 15 25 Percent Serum (F BS) in Medium shown. In these experiments, the medium was renewed at zero time.
A 10-min exposure to 45°C raised the extrapolation number from about 3 to about 14 within 2 hr. It then dropped back to the control value by approximately 5 hr. This interchange, the rapid increase in extrapolation number in the early period followed by a large increase in apparent Do raises the possibility that the "Do" in these experiments really only related to the initial portion of the survival curve and that the terminal portion (which would give the "true" Do) was never reached. As far as the minimum temperature required for the induction of thermal tolerance is concerned, Henle et al.
Plateau phase HA-I cells were heated to 4SOC foreitherO (A) or 20 min (B). The cells were then immediately exposed to the indicated temperatures for the times shown on the abscissas of each panel. The differences between the curves in panels A and B are twofold: no shoulders are seen in survival curves from the preheated cells , and the slopes of curves obtained from preheated cells subsequently exposed to temperatures below 43°C are markedly steeper than those from control cells. Unpubli shed data from Li and Hahn .