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By Devita V.T.

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RNA In RNA, the pyrimidine uracil replaces the DNA base thymine, and the pentose ribose is used instead of deoxyribose in DNA. During the synthesis of RNA from a DNA template, adenine in DNA is transcribed into uracil in RNA. Because the pentose ribose is used in RNA instead of deoxyribose, this produces a ribonucleotide having a 2' OH group on the sugar, whereas the 2' OH group is not present in DNA. The important consequence is that RNA is much less stable than DNA. RNA is highly base labile.

Stanley Smith, MD Professor of Surgery Pennsylvania State University College of Medicine Milton S. Hershey Medical Center Hershey, Pennsylvania Phyllis M. Smith, MS, LCSW Senior Clinical Social Worker Department of Social Work Yale-New Haven Medical Center New Haven, Connecticut Edward L. Snyder, MD Professor of Laboratory Medicine Yale University School of Medicine Director, Blood Bank Yale-New Haven Hospital New Haven, Connecticut Wiley W. Souba, MD, ScD, MBA Waldhausen Professor and Chair Department of Surgery Pennsylvania State University College of Medicine Hershey, Pennsylvania Ira J.

The hallmark of this book from its inception to the present and a major reason it has gained worldwide acceptance as a definitive source of cancer information has been the description of the treatment of cancer patients by stage of presentation with a tightly coordinated description of the role of each of the treatment modalities in the care of individual patients. To ensure a balanced multidisciplinary approach, each of the major treatment chapters is co-authored by a surgeon, a medical oncologist, and a radiation oncologist.

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