By Val R. Adams
A severe evaluation our present realizing of camptothecins, their shortcomings, and of the chances for bettering their scientific functionality. The authors talk about new camptothecin analog improvement, drug supply matters for optimizing their anticancer job, and their power use in various diversified cancers. extra chapters describe what's identified concerning the biochemistry, the pharmacology, and the chemistry of the camptothecins, together with the mechanism of topoisomerase and the way camptothecins poison this enzyme, using animal versions in defining the anticancer strength of camptothecins, and the query of camptothecin resistance.
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Duann P, Sun M, Lin CT, Zhang H, Liu LF. 1999 Plasmid linking umber change induced by topoisomerase I-mediated DNA damage. Nucleic Acids Res 27:2905–2911. 114. Desai SD, Liu LF, Vazquez-Abad D, D’Arpa P. 1997 Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem 272: 24159–24164. 115. Mao Y, Desai SD, Ting CY, Hwang J, Liu LF. 2001 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J Biol Chem 276:40652–40658.
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