By Ernest Hamel MD (auth.), Tito Fojo MD, PhD (eds.)
The family members of proteins referred to as the tubulin and the microtubules they shape once they mixture are very important within the mobile and, as we're more and more studying, vital in ailments that afflict such a lot of. This box of research is a testomony to how very important either easy and scientific sciences are in knowing affliction mechanisms and making inroads into cures. Microtubule ambitions in melanoma Therapy offers the 1st finished exploration of the dynamic power of microtubules anti-cancer ambitions. Written by way of prime anti-cancer researchers, this groundbreaking quantity collects the most up-tp-date microtubule examine on hand. one of the subject matters tested during this quantity are compounds that have interaction with tubulin, mechanisms and rules by means of microtubule-associated proteins and medicine, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases.
Without the elemental clinical wisdom that has been accrued – to which the individuals of this paintings have contributed enormously – we'd no longer be within the place we discover ourselves as we more and more comprehend disorder and advancing remedies. Microtubule objectives in melanoma Therapy contributes to this new wisdom, and the textual content might be a useful source for melanoma researchers, oncologists, pharmacologists, and clinical chemists.
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Extra info for The Role of Microtubules in Cell Biology, Neurobiology, and Oncology
Example text
If a cell line or a tumor is resistant to both a taxane and a vinca alkaloid the primary mechanism of resistance cannot be a microtubule polymer-based mechanism, the emphasis of this review. Thus, the question can be asked, do the molecular mechanisms of antimitotic drugs explain these observations about drug resistance? This review critically covers the essential features of tubulin and microtubule structure, microtubule assembly and dynamics, and the role of microtubule associated proteins, referred to as MAPs and dynamics regulators, in controlling microtubule assembly.
Alterations in microtubule polymer levels can cause drug resistance. (Panel A) Taxol resistance occurs when microtubules are destabilized (indicated by the large dissociation arrow) thus opposing the formation of taxol-stabilized microtubules. Microtubule destabilization can reflect alterations in isotype levels, a decrease in activity or concentration of microtubule stabilizers, or an increase in activity or concentration of microtubule destabilizers (7). (Panel B) Vinblastine resistance occurs when microtubules are stabilized (indicated by the large association arrow) thus opposing the formation of vinblastine-induced spirals.
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