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By J. Verweij, H.M. Pinedo

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Extra info for Targeting Treatment of Soft Tissue Sarcomas (Cancer Treatment and Research)

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Concurrent chemoradiation with doxorubicin-based regimens reportedly produces favorable local control rates for patients with soft tissue sarcoma (30,31). The initial experience involved intra-arterial doxorubicin combined with high-dose-per-fraction radiation therapy in patients with extremity soft tissue sarcomas. Since those findings were 49 published, several groups have attempted to evaluate the optimal route of administration (30,32-35), alternative chemotherapeutic agents (36-38), and the toxicity of combined therapies (39).

Role of radiation in the management of adult patients with sarcoma of soft tissue. Semin Surg Oncol 1994;10(5):347-56. 13. Emami B, Graham MV, Michalski JM, Perez CA. Three-Dimensional Conformal Radiation Therapy: Clinical Aspects. In: Perez CA, Brady LW, editors. Principles and Practice of Radiation Oncology. 3rd ed. Philadelphia: Lippincott-Raven; 1998. p. 371-386. 14. Knoos T, Kristensen I, Nilsson P. Volumetric and dosimetric evaluation of radiation treatment plans: radiation conformity index.

Members of the Musculoskeletal Tumor Society [see comments]. J Bone Joint Surg Am 1996;78(5):656-63. 2. O’Sullivan B, Wunder J, Pisters PW. Target description for radiotherapy of soft tissue sarcoma. In: Gregoire V, Scalliet P, Ang KK, editors. Clinical target volumes in conformal radiotherapy and intensity modulated radiotherapy. Heidelberg: Springer; 2003. p. 205-227. 3. O’Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, Wunder J, Kandel R, Goddard K, Sadura A, Pater J, Zee B. Preoperative versus postoperative radiotherapy in softtissue sarcoma of the limbs: a randomised trial.

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