By J.A. Walker-Smith, E. Lebenthal, D. Branski, W. Kiess
power inflammatory bowel affliction (IBD) encompasses Crohn's affliction, ulcerative colitis and indeterminate colitis. The particular phenotype in pediatric and adolescent sufferers and the adaptation from grownup IBD make early-onset IBD a different subgroup requiring particular healing concerns. during this ebook, prime specialists from the us, Europe and Israel current new info at the genetics, epidemiology, pathology and pathogenesis of pediatric IBD. Imaging and endoscopy within the prognosis of IBD also are mentioned. large insurance is given to sickness administration, i.e. pharmacological, dietary and surgical methods, with distinctive emphasis on development failure and behind schedule puberty. the real subject of transition from pediatric to grownup treatment is highlighted and a scientific and developmental timeline is proposed. delivering useful details on IBD in babies, children, teenagers, young people and teenagers, this e-book is key interpreting for gastroenterologists, specifically pediatric gastroenterologists and trainees, in addition to common pediatricians and nutritionists.
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Extra info for Pediatric Inflammatory Bowel Disease: Perspective and Consequences (Pediatric and Adolescent Medicine Vol 14)
Sample text
J Pediatr Gastroenterol Nutr 2005;41:49–55. 3 Montgomery SM, Ekbom A: Epidemiology of inflammatory bowel disease. Curr Opin Gastroenterol 2002;18:416–420. 4 Binder V: Epidemiology of IBD during the twentieth century: an integrated view. Best Pract Res Clin Gastroenterol 2004;18:463–479. 5 Moyer MS: A collaborative effort to define the epidemiology of pediatric inflammatory bowel disease: what can we learn from children with early-onset disease? J Pediatr 2005;146:7–8. 6 Heyman MB, Kirschner BS, Gold BD, et al: Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry.
Although no immunodeficiency could be identified, an underlying defect cannot be excluded. Environmental Risk Factors for Childhood Onset Inflammatory Bowel Disease The lack of total concordance of disease among monozygotic twins, differences in rates of IBD among migrant populations and the rising incidence support a role for environmental factors in the development of IBD. Epidemiology in Pediatric IBD 23 Seasonality of Date of Birth and Childhood onset IBD Several studies looked at the months of birth and risk for IBD.
IBD5 and Phenotypic Associations There are inconsistent data regarding phenotypic association. A UK case-control study first reported an association with perianal CD [76]. More recently, the Scottish study mentioned above found an association with markers of more severe disease such as stricturing or penetrating CD or the need for surgery. No association with disease location or UC was seen in this study [64]. A study of 981 IBD patients from Leuven could not demonstrate an association of OCTN1 and OCTN2 variants with UC, CD or IBD globally but did show an association with perianal and penetrating CD [77].