By Gunter Wolf
We're at present dealing with an alarming weight problems epidemic, with its famous health and wellbeing effects resembling metabolic syndrome/type 2 diabetes, cardiovascular ailments, an elevated occurrence of particular types of melanoma, musculoskeletal issues and pulmonary illnesses. Experimental and medical proof collected lately now means that weight problems has additionally a big impression on renal constitution and serve as. because the adipocyte is taken into account a resource of many hormones and cytokines, weight problems has even more direct impacts on renal functionality along with mediating high blood pressure. it will possibly on its own set off renal sickness resembling focal segmental glomerulosclerosis, but additionally, generally, result in development of persistent renal ailments. the current quantity is the 1st accomplished compilation devoted to this crucial subject, that includes discussions of pathophysiological in addition to medical features written by means of the leaders during this rising box of study. It brings jointly pathophysiological strategies on how weight problems impacts renal constitution and serve as, stories the epidemiology of the matter and gives healing feedback. This ebook is usually recommended for internists, nephrologists, hypertensiologists, cardiologists, and urologists treating sufferers with weight problems and renal illnesses. additionally, uncomplicated scientists reminiscent of renal physiologists, renal pathologists, pharmacologists, biochemists, and epidemiologists who desire a accomplished evaluation of the subject also will cash in on this e-book.
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Extra info for Obesity And the Kidney (Contributions to Nephrology)
Sample text
Evans S, Michael R, Wells H, Maclean D, Gordon I, Taylor J, et al: Drug interaction in a renal transplant patient: cyclosporin-Neoral and orlistat. Am J Kidney Dis 2003;41:493–496. Praga M, Hernandez E, Andres A, Leon M, Ruilope LM, Rodicio JL: Effects of body-weight loss and captopril treatment on proteinuria associated with obesity. Nephron 1995;70:35–41. Herwig-Ulf Meier-Kriesche, MD Transplant Nephrologist, University of Florida 1600 SW Archer Road, Box 100224 Gainesville, FL 32610–0224 (USA) Tel.
This translates into better survival in this population where malnutrition and its inevitable accompaniment, infection is one of the major contributors to death. This stands in direct opposition to the situation in the general population, where obesity is clearly a risk factor for excess cardiovascular mortality. This phenomenon has been termed the risk factor paradox or reverse epidemiology in uremia [10]. In contrast to the impact of BMI in the ESRD population and similar to the general population, higher BMIs have been shown to be associated with increased patient mortality in transplantation.
Hjelmesaeth J, Jenssen T, Hagen M, Egeland T, Hartmann A: Determinants of insulin secretion after renal transplantation. Metabolism 2003;52:573–578. Kasiske BL, Snyder JJ, Gilbertson D, Matas AJ: Diabetes mellitus after kidney transplantation in the United States. Am J Transplant 2003;3:178–185. Cosio FG, Pesavento TE, Kim S, Osei K, Henry M, Ferguson RM: Patient survival after renal transplantation: IV. Impact of post-transplant diabetes. Kidney Int 2002;62:1440–1446. Srinivas/Meier-Kriesche 40 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 Cosio FG, Kudva Y, van der Velde M, Larson TS, Textor SC, Griffin MD, et al: New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation.