Download Methylxanthines by Bertil B. Fredholm (auth.) PDF

By Bertil B. Fredholm (auth.)

In the current quantity of the guide of Experimental Pharmacology popular specialists describe the activities of alternative xanthines with a spotlight on caffeine and theophylline. a distinct bankruptcy is dedicated to theobromine, an energetic section of chocolate, the activities of that are much less good characterised. This booklet additionally provides the pharmacology of 1 xanthine by-product, propentofylline, to illustrate of a xanthine that has undergone vast improvement for a unique healing area.

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4 Pharmacokinetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Sources of Variation in Theophylline Pharmacokinetics and Metabolism . . . . . . 7 Metabolites and Metabolic Pathway . . . . . . . . . . . . .

3 Excretion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Pharmacokinetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Sources of Variation in Theobromine Pharmacokinetics and Metabolism . . . . . . 7 Metabolites and Metabolic Pathway .

Ashihara et al. Distribution, Biosynthesis and Catabolism of Methylxanthines in Plants 17 (Coffea arabica) and tea (Camellia sinensis), the available evidence suggests that the pathway is essentially the same in other methylxanthine-forming plants (Ashihara et al. 1998; Zheng et al. 2002; Koyama et al. 2003). 1 Formation of 7-Methylxanthine The formation of monomethylxanthine in the main caffeine biosynthetic pathway is initiated by the conversion of xanthosine to 7-methylxanthosine (Fig. 3). 158).

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