By Rudolph M. Navari
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Additional info for Management of Chemotherapy-Induced Nausea and Vomiting: New Agents and New Uses of Current Agents
Sample text
G. g. see [82]) to provide evidence to include or dismiss this option. It is of course possible that cisplatin could be acting directly on the AP as it rapidly accesses the brainstem although the levels are <20-fold lower than in the plasma at the same time points (house musk shrew, [43]). e. the circulation) which are a prominent feature of the AP [96]. Astrocytes are known to possess the organic cation transporter responsible for uptake of cisplatin, and studies in rat hippocampus have shown binding of cisplatin to rough endoplasmic reticulum in astrocytes with end-feet contacting vessels [182].
Am J Physiol Gastrointest Liver Physiol 280(5):G850–G857 48. Farmer AD, Al Omran Y, Aziz Q, Andrews PLR (2014) The role of the parasympathetic nervous system in visually induced motion sickness: systematic review and meta-analysis. Exp Brain Res 232(8):2665–2673. 1007/s00221-014-3964-3 49. Farmer AD, Ban VF, Coen SJ, Sanger GJ, Barker GJ, Gresty MA, Giampietro VP, Williams SC, Webb DL, Hellstrom PM, Andrews PLR, Aziz Q (2015) Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans.
E. the circulation) which are a prominent feature of the AP [96]. Astrocytes are known to possess the organic cation transporter responsible for uptake of cisplatin, and studies in rat hippocampus have shown binding of cisplatin to rough endoplasmic reticulum in astrocytes with end-feet contacting vessels [182]. The functional consequences of such uptake if it occurred in the AP astrocytes are unknown but could prove a credible mechanism by which cisplatin could modulate the outflow of the AP to the NTS.