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By Blair A. Jobe, MD, Charles R. Thomas, Jr., John G. Hunter

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Extra resources for Esophageal Cancer: Principles and Practice

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In some cases, the stenotic esophageal walls contain tracheobronchial remnants such as respiratory epithelium or hyaline cartilage, which indicate associated abnormalities of lineage. Esophageal duplication is a rare condition occurring in 1 in 8,000 live births. They present as cystic or tubular, resulting as an abnormality of the epithelial, submucosal, or muscular layers. 6), which do not communicate with the luminal space. These structures can be lined with different types of epithelium, such as squamous, cuboidal, or pseudostratified and gastric mucosa, and can present with intracystic hemorrhages.

This chapter details esophageal anatomy and places its principal components into clinical context. ANATOMIC LANDMARKS The esophagus is a flattened muscular tube of 18 to 26 cm in length, from the upper sphincter to the lower sphincter, connecting the pharynx to the stomach. The esophagus starts at approximately 18 cm from the incisors at the pharyngoesophageal junction (C5–6 vertebral interspace at the inferior border of the cricoid cartilage) and descends anteriorly to the vertebral column spanning the superior and then the posterior mediastinum (1).

Roberts DJ, Johnson RL, Burke AC, et al. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development. 1995;121(10):3163–3174. 13. Ishii Y, Rex M, Scotting PJ, et al. Region-specifi c expression of chicken Sox2 in the developing gut and lung epithelium: regulation by epithelial-mesenchymal interactions. Dev Dyn. 1998;213(4):464–475. 14. Skandalakis JE, Gray SW. Embryology for Surgeons. 2nd ed. B. Saunders; 1994. 15. Litingtung Y, Lei L, Westphal H, et al.

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