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1996. Telomerase activity in human breast tumors. J. Natl. Cancer Inst. 88(2):116–122. 61. Hess JL and Highsmith WE Jr. 2002. Telomerase detection in body fluids. Clin. Chem. 48(1):18–24. 26 Kasahara and Tsukada 62. Bilous M. 2001. HER2 Testing Advisory Board. HER2 testing recommendations in Australia. Pathology 33(4):425–427. 63. Hung M, Dorsey JF, Epling-Burnette PK, et al. 2002. Inhibition of Bcr-Abl kinase activity by PD 180970 blocks constitutive activation of Stat5 and growth of CML cells.

A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33:49–53. Changing Role of the Pathologist 27 3 The Changing Role of the Pathologist in the Management of the Cancer Patient Raymond B. Nagle 1. 1. The Difficult Diagnosis The experienced surgical pathologist routinely uses paraffin embedded tissue stained with hematoxylin and eosin (H&E) to establish the correct cancer diagnosis. A number of circumstances arise, however, in which the H&E slide is insufficient to establish the correct diagnosis.

ZD1839 (Iressa): What’s in it for the patient? Oncologist 7(4):25–30. 66. Herbest RS. 2002. Targeted therapy in non-small-cell lung cancer. Oncology 9(9):19–24. 67. Whang YE, Wu X, Suzuki H, et al. 1998. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl. Acad. Sci. USA 95(9):5246–5250. 68. Neshat MS, Mellinghoff IK, Tran C, et al. 2001. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl. Acad.

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