By Lodovico Balducci (Editor), Martine Extermann (Editor)
Organic foundation of Geriatric Oncology highlights learn concerns which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and remedy, in response to the biologic interactions of melanoma and age. It illustrates the advantage of the rules of geriatrics within the administration of melanoma within the older person. This quantity presents a body of reference for practicioners of any specialties desirous about the administration of older sufferers and for oncologists keen on the administration of melanoma of older participants. it's a resource for uncomplicated and scientific scientists exploring the interactions and rising details of melanoma and getting older.
Read or Download Biological Basis of Geriatric Oncology (Cancer Treatment and Research) PDF
Similar oncology books
The gastrointestinal music offers one of many exact structures the place a number of malignancies, together with adenocarcinoma of the pancreas, esophagus and colon are every one linked to weight problems. This specific organization is roofed during this quantity of power stability and melanoma from the epidemiologic, biologic and power etiologic point of view.
With an annual price of greater than 12 million worldwide diagnoses and seven. 6 million deaths, the societal and fiscal burden of melanoma can't be overstated. mind metastases are the commonest malignant tumors of the primary worried method, but their occurrence seems to be expanding inspite of the development of melanoma cures.
This quantity develops effects on non-stop time branching techniques and applies them to check price of tumor development, extending vintage paintings at the Luria-Delbruck distribution. for that reason, the writer calculate the chance that mutations that confer resistance to remedy are current at detection and quantify the level of tumor heterogeneity.
- Targeted Cancer Treatment in Silico: Small Molecule Inhibitors and Oncolytic Viruses
- The Molecular Basis of Human Cancer
- Head and Neck Cancer Imaging
- Brain Metastases from Primary Tumors, Volume 3. Epidemiology, Biology, and Therapy of Melanoma and Other Cancers
- The Official Patient's Sourcebook on Islet Cell Carcinoma: A Revised and Updated Directory for the Internet Age
- Cancer of the Larynx: Current Concepts in the Treatment of the Neck (ORL)
Additional resources for Biological Basis of Geriatric Oncology (Cancer Treatment and Research)
Eur J Cancer 2001; 37:S114S117 70. Ponten J: Cell biology of precancer. Eur J Cancer 2001; 37:S97-S113 71. Vijg J: Somatic mutations and aging: a re-evaluation. Mutat Res. 2000; 447:117-135 72. Matoha HF; Cosgrove JW; Atak JR; Rapoport SI: Selective elevation of c-myc transcript levels in the liver of the aging Fischer-344 rat. Biochem Biophys Res Commun 1987; 147:1-7 73. Ono T; Uehara Y; Kurishita A; Tawa R; Sakurai H: Biological significance of DNA methylation in the aging process. Age & Aging 1993; 22:534-543 74.
Age is considered as a variable because older cells may already present in advanced carcinogenic stages, are primed to the effects of environmental carcinogens and consequently may develop cancer more rapidly and at higher rate when exposed to these substances. A number Figure 3. The multistage carcinogenesis inducted by single exposure to a carcinogenicagent at different ages. BIOLOGICAL INTERACTIONS 23 of factors, including genetic predisposition, oxidative stress, and previous exposure to carcinogens may be responsible of the molecular changes that prime aging cells to environmental carcinogens.
The character of these changes could vary in different tissues and might cause uneven tissue aging. Dolle et al. 88 using a lacZ plasmid transgenic mouse model, determined spectra of spontaneous point mutations in different organs in young and old mice. While similar at a young age, the mutation spectra among these organs were significantly different in old age. The authors stressed that the replicative history per se is not the underlying causal factor of age-related organ-specific differences in mutations spectra.