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By David A Gewirtz (Editor), Shawn Edan Holt (Editor), Steven Grant (Editor)

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Mol Cell Biol 2002; 22:3509–17. 190. Clausen T, Southan C, Ehrmann M. The HtrA family of proteases: implications for protein composition and cell fate. Mol Cell 2002; 10:443–55. 191. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 2001; 8(3): 613–21. 192. Hegde R, Srinivasula SM, Zhang Z, et al. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.

Dysregulation of apoptosis in cancer. J Clin Oncol 1999; 17(9):2941–53. 16. Makin G, Hickman JA. Apoptosis and cancer chemotherapy. Cell Tissue Res 2000; 301:143–52. 17. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis. A link between cancer genetics and chemotherapy. Cell 2002; 108(2):153–64. 18. Schmitt CA, Fridman JS, Yang M, et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109:335–46. 19. Roninson IB. Tumor cell senescence in cancer treatment.

32. Ruchaud S, Korfali N, Villa P, et al. Caspase-6 gene knockout reveals a role for Lamin A cleavage in apoptotic chromatin condensation. EMBO J 2002; 21:1967–77. 33. Kothakota S, Azuma T, Reinhard C, et al. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 1997; 278(5336):294–8. Chapter 1 / The Intrinsic Pathway of Apoptosis 21 34. Kamada S, Kusano H, Fujita H, et al. A cloning method for caspase substrates that uses the yeast twohybrid system: cloning of the antiapoptotic gene gelsolin.

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