By S. González-Moreno
Malignant peritoneal affliction in its a number of varieties is a devastating situation for sufferers who are suffering from it and it poses an important problem for the clinicians caring for them. learn efforts during this box have frequently been scarce lower than the belief of a uniformly deadly and hopeless outcome.
In the previous couple of many years a renewed curiosity in peritoneal carcinomatosis and first peritoneal malignancies has happened. remarkable beneficial effects pronounced with the employment of competitive cytoreductive surgical procedure mixed with perioperative intraperitoneal chemotherapy have catalysed a transformation within the belief and therapy choices for those illnesses. chosen sufferers can now be provided a curative-intent mixture treatment, while long ago merely the absolute best palliation can be considered.
This booklet is a accomplished compilation of the hot wisdom in peritoneal floor oncology within the sunrise of the twenty-first century. It covers the full spectrum of the most recent study performed in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the most recent scientific trials. also, the necessities of perioperative intraperitoneal chemotherapy and the trendy histopathological evaluation of peritoneal floor malignancy are reviewed. a distinct old viewpoint on how this new wisdom has spread out through the years is helping indicate the longer term learn instructions to be pursued. major specialists during this box from worldwide, together with the pioneers who gave start to this new period in oncology, shape an unbeatable and impressive panel of authors.
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Extra resources for Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research)
Example text
Yonemura Y, Eno Y, Tabata K et al. (2005) Role of VEGF-C and VEGF-D on lymphangiogenesis in gastric cancer. Int J Clin Oncol 10:318–327 18. Shimotsuma M, Simpson-Morgan MW, Takahashi T et al. (1992) Activation of omental milky spots and milky spot macrophages by intraperitoneal administration of a streptococcal preparation, OK-432. Cancer Res 52:5400–5402 19. Esperanca MJ, Collins D (1966) Peritoneal dialysis efficiency in relation to body weight. J Ped Surg 1:162–169 20. Inoue H, Matsuyama A, Mimori K et al.
Benevolo M, Mottolese M, Cosimelli M et al. (1998) Diagnostic and prognostic value of peritoneal immunocytology in gastric cancer. J Clin Oncol 16:3406– 3411 33. Juhl H, Stritzel M, Wroblewski A et al. (1994) Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients. Int J Cancer 57:330–335 34. Asao T, Fukuda T, Yazawa S et al. (1991) Carcinoembryonic antigen levels in peritoneal washings can predict peritoneal recurrence after curative resection of gastric cancer.
However, Yonemura et al. demonstrated that CEA levels in wash fluid are not an independent predictor for peritoneal dissemination, and that their accuracy is inferior to that of cytological examination [36]. When the results were studied according to the combination analyses of peritoneal wash 19 cytology and CEA-RT-PCR, the prognosis of patients with positive CEA-RT-PCR or positive cytology was significantly poorer than that of those with negative CEA-RT-PCR and peritoneal wash cytology (Fig. 8).