Download Post-Genome Biology of Primates by Hirohisa Hirai, Hiroo Imai, Yasuhiro Go PDF

By Hirohisa Hirai, Hiroo Imai, Yasuhiro Go

In 2001, first studies of the human draft genome have been released. in view that then, genomes of many different organisms were sequenced, together with numerous primate species: the chimpanzee, rhesus macaque, gorilla, orangutan, gibbon, baboon, marmoset, tarsier, galago, lemur, and extra lately Neanderthals. In a brand new period of "post-genome biology", scientists now have the enormous volume of knowledge printed via genome learn to confront essentially the most tough, primary questions in primatology and anthropology: What makes us human? This quantity contains a suite of articles on numerous issues suitable to primate genomes, together with evolution, human origins, genome constitution, chromosome genomics, and bioinformatics. The e-book covers the state of the art examine in molecular primatology and gives nice insights into the sensible range of primates. This beneficial assortment will profit researchers and scholars, together with primatologists, anthropologists, molecular biologists, evolutionary biologists, and animal behaviorists.

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Extra resources for Post-Genome Biology of Primates

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I. The glycophorins and their possible role in evading malaria parasites. Mol Biol Evol 20:1795–1804 22 N. Osada Wang Z, Lewis MG, Nau ME et al (2004) Identification and utilization of inter-species conserved (ISC) probesets on affymetrix human genechip platforms for the optimization of the assessment of expression patterns in non human primate (NHP) samples. BMC Bioinformatics 5:165 Wang HY, Chien HC, Osada N et al (2007) Rate of evolution in brain-expressed genes in humans and other primates.

However, this decrease apparently already starts early in childhood, around 4 years of age (vertical line), implying a connection between developmental processes and aging. The rhesus macaque (gray squares) also shows a parallel decrease in expression levels with age, although the trend starts earlier than in humans seen in aging reflect regulatory patterns established in development. As already mentioned, such senescence-driving developmental regulation, recently observed in model organisms, involved both miRNA and transcription factors (Boehm and Slack 2005; Budovskaya et al.

1). What makes this change more amazing is that the brain is an expensive tissue, that is, it demands large amounts of energy to function (Aiello and Wheeler 1995). Along with large brains, humans have evolved unique cognitive abilities, especially communication skills and the use of abstract symbols, which have dramatically increased the pace of cultural accumulation and niche construction (Smith and Szathmary 1998; Laland et al. 2001). The question is: how could humans evolve into such a phenotypically distinct species over such a short evolutionary time?

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