By Otto Wieland (auth.), Professor Dr. med. Dr. rer. nat. h. c. Dr. med. h. c. Hans H. Weber (eds.)
The Meyerhof Symposium on "Molecular Bioenergetics and Macromolecular Biochemistry" came about in Heidelberg from the fifth to the eighth of July, 1970. The timing was once selected to coincide with the production of a brand new chair, within the Weizmann Institute of technological know-how in Rehovot, in reminiscence of OTTO MEYERHOF and the site was resolute by way of the truth that loads of MEYERHOF'S clinical paintings was once performed in Heidelberg. The ancient reason behind the symposium was once the pressing wish of many major biochemists and physiologists lively in Molecular Biology to honour the reminiscence of 1 of the best scientists during this box and likewise one of many maximum biologists of the twentieth century. October 1971 is the 20th anniversary of the dying of OTTO MEYERHOF and 1972 marks 50 years given that he was once presented the Nobel prize (1922). with reference to the age of a few of his buddies and students it used to be made up our minds the symposium to be prepared in 1970, the 1st of the 3 commemorative years.
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Additional resources for Molecular Bioenergetics and Macromolecular Biochemistry: Meyerhof-Symposium Heidelberg, July 5–8, 1970
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Zur Isolierung und Trennung der gebildeten Methylsalicylsaure und Fettsauren wurde das angesauerte Reaktionsgemisch mit Ather extrahiert, die extrahierten Sauren wurden mit Diazomethan verestert und die Methylester gaschromatographisch getrennt. In Abb. 11 ist das Resultat einer typischen Enzymbestimmung am rohen Mycelextrakt wiedergegeben. 2 6000 cpm 4000 >, ~ > 2000 ~ o o -0 o a: o 24 Time Abb. 11. Methode zur Bestimmung der Methylsalicylsauresynthetase durch Gaschromatographie [23] * Sie sind hauptsachlich durch zugesetzte Sauren als "Trager" verursacht.
Nachdem anschlieBend die "zentrale" Sulfhydrylgruppe einen Malonylrest aus Malonyl-CoA iibernommen hat, kommt es zur Kondensation zwischen den gebundenen Essigsaure- und Malonsaureresten unter Bildung von Acetessigsaure, die in Bindung an der "zentralen" Sulfhydrylgruppe entsteht. Der schrittweise "Obergang zur Buttersaure erfolgt iiber D-,B-Hydroxy-buttersaure und Crotonsaure unter Verbrauch von zwei Molekiilen TPNH als Reduktionsmittel, wobei im zweiten Reduktionsschritt Flavinmononucleotid als Wasserstoffiibertrager eingeschaltet ist.
Chern. ). Houston, Texas: Robert A. Welch Found. 1962, p. 293. 7. : Eur. J. Biochem. 15, 483 (1970). 8. : Eur. J. Biochem. 8, 503 (1969). 9. VAGELOS, P. , MAJERUS, P. , ALBERTS, A. , LARRABEE, A. : Federation Proc. 25, 1485 (1966). 10. VANAMAN, T. , WAKIL, S. , HILL, R. : J. BioI. Chern. 243, 6420 (1968). 11. : Dissertation Universitat Munchen, 1963. 12. : Eur. J. Biochem. 13, 55 (1970). 13. : Dissertation Universitat Munchen, 1970. 14. : Eur. J. Biochem. 10, 377 (1969). 15. , SCHERAGA, H. : J.