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A. Wickenden, B. Priest and G. Erndemli, Future Med. , 2012, 4(5), 661. 4. R. Sabatowski, D. Schaefer, S. M. Kasper, H. Brunsch and L. Radbruch, Curr. Pharm. , 2004, 10(7), 701. 5. J. Wojnar, Chem. N. , 2007, 71(1), 20. 6. W. O. Foye, in Foye’s Principles of Medicinal Chemistry, ed. D. A. Williams and T. L. Lemke, Lippincott, Williams & Wilkins, Philadelphia, PA, 2002, p. 4. 7. S. Stolc, Gen. Physiol. , 1988, 7, 177. View Online 10:37:33. 1039/9781849735087-00001 14 Chapter 1 8. C. H. Large, M.
Of course a very limited number of compounds could be examined with these types of assays, so the breadth of chemical matter investigated was severely compromised. 1 Number of publications per year using the search term ‘‘Ion Channel AND High Throughput Screen’’, 1995–present, from the Sciverse Scopus search tool. The solid line is a fit of an exponential function to the data. View Online 20 Chapter 2 10:37:37. 4 A Brief History of Ion Channel HTS Methodologies Here we will overview methods to study the interaction of test substances with ion channels.
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