Download Dermal Replacements in General, Burn, and Plastic Surgery: by Gerd G. Gauglitz MD, MMS, Jürgen Schauber MD (auth.), PDF

By Gerd G. Gauglitz MD, MMS, Jürgen Schauber MD (auth.), Lars-Peter Kamolz, David Benjamin Lumenta (eds.)

The dermis is the most important human organ method. lack of epidermis integrity because of damage or disorder ends up in a considerable physiologic imbalance and finally in critical incapacity or dying. the commonest explanation for major epidermis loss is thermal damage, via trauma and persistent ulcerations.

Over the prior a long time striking advances were made within the realizing of mobile and molecular methods of wound therapeutic and the pathobiology of power wounds. this data has resulted in wound care techniques that facilitate extra quick closure of wounds with higher practical and aesthetic end result. a smart and resource-saving usage of those leading edge applied sciences calls for a vast wisdom of those techniques and innovations.

This e-book intends to provide an summary approximately modern-day wound care advancements in tissue engineering and epidermis alternative. It offers various symptoms and diversities of scientific purposes to assist the health practitioner choose a selected process for every scientific situation.

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Extra resources for Dermal Replacements in General, Burn, and Plastic Surgery: Tissue Engineering in Clinical Practice

Example text

Bayat Wound site Epidermis Dermis d an n tion o i a s r he mig Ad ns tra Soluble mobilization and homing signals released into surrounding tissue and blood stream Adherens junction Signal gradient Cell-matrix interaction Paracrine signalling Enzymatic action Niche specific cell attachment sites ing oll m e St c r ell el ss d oo Bl ve Fig. 3 Schematic representation of stem cell migration stimulated by biomaterial factor release. Stem cells recruited migrate through vascular system adjacent to implanted factor releasing biomaterial.

Exp Dermatol 17(7):592 Knoepfler PS (2009) Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 27(5):1050–1056 Kocher A et al (2006) Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC Chemokines. J Mol Cell Cardiol 40(4):455–464 Kolokol’chikova E et al (2001) Morphological changes in burn wounds after transplantation of allogenic fibroblasts. Bull Exp Biol Med 131(1):89–93 Kränkel N et al (2011) Targeting stem cell niches and trafficking for cardiovascular therapy.

Science 282(5391):1145 Tiede S et al (2007) Hair follicle stem cells: walking the maze. Eur J Cell Biol 86(7):355–376 Togel F, Westenfelder C (2007) Adult bone marrow-derived stem cells for organ regeneration and repair. Dev Dyn 236(12):3321–3331 Uchida N et al (2001) Transplantable hematopoietic stem cells in human fetal liver have a CD34+ side population (SP) phenotype. J Clin Invest 108(7):1071–1077 Unzek S et al (2007) SDF-1 recruits cardiac stem cell-like cells that depolarize in vivo. Cell Transplant 16(9):879–886 Utsunomiya T et al (2011) Human adipose-derived stem cells: potential clinical applications in surgery.

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