By Pier Carlo Braga, Davide Ricci
Hugely skilled physicians and biologists sincerely clarify the elemental technical wisdom had to use AFM and reveal its multifarious makes use of in biomedicine and the existence sciences. The functions variety generally from morphostructural analyses of mobile constructions, to the research of subcellular buildings, to useful investigations, and show a strong new approach of organic samples. The tools sincerely exhibit the benefits of AFM over conventional lifestyles technology microscopy, between them simultaneous very excessive magnification and backbone, minimum tissue and cellphone education, and the facility to procure diversified perspectives of the pattern from a unmarried facts assortment.
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Mass-spectroscopy, high-performance liquid chromatography, surface plasmon resonance [SPR]) and the chip technologies (for example, gene-arrays) with their advantage of easy multiplexing capabilities, albeit with their need for fluorescence labeling and restriction to higher molecular-weight compounds like proteins and nucleic acids thus far. In comparison with the methods just described, the cantilever technology is cheap, fast, sensitive, and applicable to a broad range of compounds. The lack of multiplexing could be overcome by the application of large cantilever arrays with >1000 cantilevers per chip.
Cantilever arrays are already employed as detectors in both static and dynamic modes (8,9). Recent articles show the potential for detection of DNA hybridization (3,12), cell capture, or toxin detection (1). Integrating cantilever arrays into microfluidic channels will significantly reduce the amount of sample required (14). Attempts have been made to get data from single-cantilever experiments for DNA (15) or antibody–antigen reactions (16) or from a two-cantilever setups using different stiffnesses for the individual cantilevers (17).
1996) Biosensor based on force microscope technology. Vacuum Sci. Technol. B 14, 789–793. 2. , and Jun, M. (2002) A novel ISFET-type biosensor based on P450 monooxygenases Biosensors Bioelectronics 17, 173–179. 3. , Baller, M. , Lang, H. , et al. (2000) Translating biomolecular recognition into nanomechanics. Science 288, 316–318. 4. , Lang, H. , et al (1997) Surface stress in the selfassembly of alkanethiols on gold Science 276, 2021–2024. 5. , Gerber, C. , Gimzewski, J. , Meyer, E. -J. (1996) Thermal analysis using a micromechanical calorimeter Appl.