By Rosalind Pitt-Rivers
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The animals were maintained on thiouracil and the dose of L-thyroxine required to prevent the development of goitres was determined at normal, low and elevated temperatures. At 25°C the daily secretion rate was found to be 5-2 [xg thyroxine; this rose to 9-5 (xg when the rats were kept at 1°C and fell to 1-7 [xg when the temperature was raised to 35°C. This method for determining the daily rate of thyroid hormone secretion has often been employed. By this means, Biellier and T u r n e r and Hoffmann have found that the duck secretes 18 [xg thyroxine per day during the first week of goitrogen administration.
Astwood and Bissell showed that prolonged administration of thiouracil to rats resulted in a fall in thyroidal iodine content to low levels; Astwood found however that thiouracil-treated rats could still concentrate iodine when injected with potassium iodide. VanderLaan and Bissell and VanderLaan and VanderLaan have shown that under the influence of propylthiouracil, the thyroid gland of the rat is able to concentrate large amounts of iodide, so that the thyroid: serum iodide ratio may rise to a value of 250: 1.
J o s t has studied the action of propylthiouracil on foetal thyroid function in the rat; in the normal foetus, administration of propylthiouracil to the mother produces marked hypertrophy of the foetal thyroid; this does not occur in the decapitated (hypophysectomized) foetus. It appears that in the rat, the foetal thyroid is not controlled by the foetal pituitary gland. 824 (VII) RATE OF SECRETION OF THE THYROID HORMONE INTO THE CIRCULATION Little direct evidence for the sequence of events occurring during thyroid hormone biosynthesis has been described; it has rather been inferred from the effects of hypophysectomy on intrathyroidal iodine metabolism.