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125, 137-165. , Fietzek, P. , and Kühn, Κ. (1980). J. Mol. Biol. 141, 293-314. , Fietzek, P. , Lapiere, C. , and Kühn, Κ. (1979). Eur. J. Biochem. 99, 3 1 - 3 8 . Hulmes, D. , and Miller, A. (1979). Nature (London) 282, 878-880. Hulmes, D. J. , Parry, D. , Piez, Κ. , and Woodhead-Galloway, J. (1973). J. Mol. Biol. 79, 137-148. , and Deykin, D. (1974). J. Clin. Invest. 53, 875-883. Jamieson, G. , Urban, C. , and Barber, A. J. (1971). Nature (London), New Biol. 234, 5-7. , and Hörmann, Η. (1978).

This would mean that there is no simple rela­ tionship between the triple-helical domains of different collagens and that they may have evolved in different ways. The present knowledge of the gene structure of the individual collagens does not yet allow a more detailed discussion of their evolutionary development. THE CLASSICAL COLLAGENS: TYPES I, II, AND III 37 REFERENCES Adams, E. (1978). Science 202, 591-598. , Fietzek, P. , Glanville, R. , and Kühn, Κ. (1979). Hoppe-Seyler's Ζ. Physiol. Chem.

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