By Kazuya Machida, Bernard A. Liu
This quantity covers an array of options to be had for learning SH2 domain names and phosphotyrosine signaling. The e-book is split into six elements: half I outlines the heritage of SH2, know-how improvement, and phone signaling; half II specializes in computational techniques and instruments used for id, category, and predictions of SH2 area binding companions; half III info numerous how you can arrange the SH2 domain names as experimental reagents; half IV provides tools for structural research and standard binding assays utilizing SH2 domain names; half V describes high-throughput and proteomics ways to assist in reading SH2-mediated interactions; and half VI covers functions for SH2 area to sensible and imaging analyzes. Written within the hugely profitable Methods in Molecular Biology series layout, chapters contain introductions to their respective issues, lists of the required fabrics and reagents, step by step, effectively reproducible laboratory protocols, and tips about troubleshooting and warding off recognized pitfalls.
Cutting-edge and thorough, SH2 domain names: tools and Protocols is a helpful source for computational biologists, biochemists, structural biologists, telephone biologists, pathologists, and other people drawn to SH2 domain names and phosphotyrosine signaling. Researchers who're investigating how protein interplay area mediate specificity in signaling platforms can also locate this ebook informative.
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Extra info for SH2 Domains: Methods and Protocols
Sample text
046 84. Songyang Z, Cantley LC (1995) Recognition and specificity in protein tyrosine kinase- mediated signalling. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR (2002) The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Lupher ML Jr, Songyang Z, Shoelson SE, Cantley LC, Band H (1997) The Cbl phosphotyrosine- binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
Songyang Z, Cantley LC (1995) Recognition and specificity in protein tyrosine kinase- mediated signalling. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR (2002) The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Lupher ML Jr, Songyang Z, Shoelson SE, Cantley LC, Band H (1997) The Cbl phosphotyrosine- binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR (2002) The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Lupher ML Jr, Songyang Z, Shoelson SE, Cantley LC, Band H (1997) The Cbl phosphotyrosine- binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (2008) Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.