By Bernd Nilius, Pieter de Tombe, Thomas Gudermann, Reinhard Jahn, Roland Lill, Ole H. Petersen
Best researchers are especially invited to supply a whole knowing of a key subject in the multidisciplinary fields of body structure, biochemistry and pharmacology. In a kind instantly helpful to scientists, this periodical goals to filter out, spotlight and assessment the most recent advancements in those rapidly advancing fields.
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Additional info for Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
Sample text
1 Acute Oxidative Stress in Ischemia/Reperfusion Injury . . . . . . . . . . . . . . . 2 Chronic Oxidative Stress in Heart Failure . . . . . . . . . . . . . . . . . . . . . . 4 Oxidative Posttranslational Modifications of RyR2 . . . . . . . . . . . . . . . . . . . . . 1 S-Glutathionylation . . . . . . . . . . . . . . . . . . . .
1 S-Glutathionylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 S-Nitrosylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Intersubunit Cross-Linking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2009). These RyR2 clusters align with LTCCs in the dyadic cleft via junctophilins (Garbino et al. 2009). Activation of single CRU (spontaneously or by LTCC Ca2+ current) produced a local increase of [Ca2+]i called Ca2+ spark (Cheng et al. 1993). The global Ca2+ release is the result of the spatiotemporal activation of thousands of individual CRU or Ca2+ sparks (Fig. 1). Thus, the amplitude of the global Ca2+ transient during systole is the result of local subcellular recruitment of CRUs (Stern 1992).