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By U. von Stockar, L. A. M. van der Wielen (auth.), Prof. Dr. Urs. von Stockar, Prof. Dr. L. A. M. van der Wielen, A. Bruggink, J. M. S. Cabral, S.-O. Enfors, P. Fernandes, M. Jenne, K. Mauch, D. M. F. Prazeres, M. Reuss, S. Schmalzriedt, D. Stark, U. von St

Process integration has been some of the most lively learn fields in Biochemical Engineering over the past decade and it'll remain so if bioprocessing is to develop into extra rational, effective and effective. This quantity outlines what has been completed in recent times. Written via specialists who've made vital contributions to the eu technological know-how, starting place application on method Integration in Biochemical Engineering, the amount specializes in the growth made and the main possibilities, and likewise at the obstacles and the demanding situations in bioprocess integration that lie forward. the idea that of bioprocess integration is handled at quite a few degrees, together with integration on the molecular, organic, bioreactor and plant degrees, but additionally accounting for the combination of separation and mass move operations and biology, fluid dynamics and body structure, in addition to simple technology and procedure technology.

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Ranade and Van den Akker [15]). This is often also called a multiple reference frame method [16]. An advantage compared with the sliding mesh technique is that the full time-dependent transport equations need not be solved. This offers an interesting and promising approach. However, the essential comparisons with experimental observations are lacking. 2 Gas-Liquid Flow An important feature in modeling the two-phase flow is to distinguish between Eulerian and Lagrangian approaches. In the Lagrangian approach, the continuous phase is treated as a continuum while the dispersed gas bubbles are modeled as single particles.

Biotechnol Bioeng 48:559–572 17. van Berlo M, Gude MT, van der Wielen LAM, Luyben KCAM (1997) Solubilities and partitioning of glycine in water+ethanol+butanol solutions. Ind Eng Chem Res 36(6): 2474–2482 18. Albertsson P-A, Johansson G, Tjerneld F (1990) Aqueous two-phase separations. In: Asenjo JA (ed) Separation processes in biotechnology. Dekker, NY, pp 287–328 19. Glatz CE (1990) Precipitation. In: Asegno JA (ed) Separation processes in biotechnology. Dekker, Basel, pp 329–356 20. Kim DW, Jeong YK, Lee JK (1994) Adsorption kinetics of exoglucanase in combination with endoglucanase from T.

61 6 Conclusions 7 References . . . . . . . . . . . . . . . 66 . . . . . . . . . . . . . . . 66 Abbreviations a avm, i Ab c cb cd ck c*O2 cvm , cvma cm cm, b m–1 m s–2 m2 – – – mol m–3 or g m–3 mol m–3 – – – db di D Deff DO2 DT fk F Fd g H H I k kL kL a Kk n nt m m h–1 m2 s–1 m2 s–1 m – N N m s–2 m bar – m2 s–2 m s–1 s–1 mol m–3 or g m–3 s–1 – specific interfacial surface area array of virtual acceleration sectional area of a bubble parameters of turbulence models constant in calculation of bubble diameter drag coefficient concentration of species k oxygen concentration at the gas-liquid interface coefficients of virtual mass force parameter of turbulence model parameter for calculation of bubble induced turbulence bubble diameter impeller diameter dilution rate turbulent dispersion coefficient diffusion coefficient of oxygen tank diameter correction factor of drag coefficient force drag force gravitational acceleration liquid height Henry-number inhomogeneity turbulent kinetic energy mass transfer coefficient volumetric mass transfer coefficient half saturation constant of species k impeller speed number of tanks Integration of Physiology and Fluid Dynamics p pO2 P Pk QL qk r rk Sk Si Sc Sct t tc ui u¢i V V˙G VT x xO2 bar bar W m2 s–3 m3 s–1 s–1 m mol m–3 s–1 or g m–3 s–1 mol m–3 s–1 or g m–3 s–1 N m–3 – – s s m s–1 m s–1 m3 m3 s–1 m3 m – yO2 Y z – – m pressure partial pressure of oxygen in the gas phase power input of the impeller production of turbulent kinetic energy liquid pumping capacity of an impeller specific rate of species k radial coordinate reaction rate of species k source of species k specific force Schmidt number turbulent Schmidt number time circulation time mean velocity component fluctuation velocity component volume gas sparging rate tank volume coordinate concentration fraction of oxygen in the liquid phase molar fraction of oxygen in the gas phase yield coefficient axial coordinate Greek letters d e eG eL j µ µ µm neff = nL + nt nL nt tm r s s td tij tp – m2 s–3 – – ° h–1 Pa s Pa s m2 s–1 m2 s–1 m2 s–1 s kg m–3 N m–1 – s – s Kronecker symbol energy dissipation rate volume fraction of gas phase volume fraction of liquid phase tangential coordinate specific growth rate dynamic viscosity modified dynamic viscosity effective viscosity laminar viscosity turbulent viscosity mixing time density surface tension parameters of turbulence models dissipation-range timescale laminar deformation tensor production-range timescale 21 22 S.

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