By Hans-Dieter Jakubke
This mini-encyclopedia includes greater than 1,500 alphabetical entries from the complete box of peptide technology in a single convenient quantity, in addition to the technical phrases, acronyms and ideas utilized in peptide chemistry. It additionally gains the whole series of greater than 800 peptides, a variety of illustrations and various cross-references.
parts coated include:
- organic peptides and small proteins
- peptide hormones
- pharmaceutical peptides
- peptide antibiotics
- peptide inhibitors
- peptide reagents
- peptide tags
- structural classes
- synthesis and purification
- analytical methods
- proteomics and peptidomics.
Condensed but obtainable, simply crucial details is displayed, largely associated through references to the hot medical literature for additional examine.
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Extra resources for Peptides from A to Z
Sample text
Sci. USA 2004, 101, 12067; T. , Org. Lett. 2006, 8, 531; D. , Chem. Eur. J. 2006, 12, 7615]. By inhibiting fibrinolysis and preserving platelet function, aprotinin has been shown to reduce blood loss and transfusion requirements in cardiac surgery, lung, and liver transplantations, and surgery for hip replacement. Additional indications are hyperfibrinolytic hemostatic disorders and complications of thrombolytic therapies. In Europe, aprotinin has been in clinical use for about 40 years, but in the United States it has been approved for intravenous applications only since 1993 [M.
Boman, Scand. J. Immunol. 1998, 48, 15; A. M. Cole, T. Ganz, BioTechology 2000, 29, 822; M. Zasloff, Nature 2002, 415, 389; H. Ulvatne, Am. J. Dermatol. 2003, 4, 591;R. E. Hancock, D. R. Devine, Mammalian Host Defence Peptides, Cambridge University Press, Cambridge, UK, 2004; C. Beisswenger, R. Bals, Curr. Prot. Pept. Sci. 2005, 6, 255; J. B. McPhee, R. E. W. Hancock, J. Peptide Sci. 2005, 11, 677; K. A. Brogden, Nat. Rev. Microbiol. 2005, 3, 238; K. L. Brown, R. E. W. Hancock, Curr. Opin. Immunol.
MI481-42F4. The amythiamicins A–D belong to the very few thiopeptides that do not contain a dehydroalanine moiety. They inhibit both the Ancovenin growth of Gram-positive bacteria, including the methicillin-resistant Staphylococcus aureus (MRSA), and the action of elongation factor Tu (EF-Tu), a GTP-dependent translation factor. 01 µM) against Plasmodium falciparum, the parasite that causes the majority of malarial infections in humans. It has been reported that amythiamicin binds to the EF-Tu of the parasite, thereby blocking protein synthesis.