Download Drug-DNA Interactions: Structures and Spectra by Kazuo Nakamoto PDF

By Kazuo Nakamoto

Study important information regarding drug-DNA interactions from Drug-DNA Interactions: buildings and Spectra , the single complete publication written approximately this subject. comprehend the categories of structural and bonding info that may be acquired utilizing particular physico-chemical equipment and detect how you can layout new medicinal drugs which are greater than present remedies and feature fewer unintended effects. locate designated information regarding X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy akin to UV-Visible absorption, fluorescence, round dichroism (CD), circulation linear dichroism (FLD), infrared (IR) and Raman spectroscopy.

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Additional info for Drug-DNA Interactions: Structures and Spectra

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The peculiarly smaller extinction coefficient of B-DNA results from the interaction of the p electrons between the base aromatic residues when they are stacked vertically. 27. (a) Absorption spectra of DNA from a crab (Cancer borealis) in aqueous solution observed at two different temperatures. 005 M phosphate buffer, pH ¼ 7. The guanine cytosine content of this DNA is only 3% [128]. At 28 C, two polydeoxyribonucleotide chains (Watson–Crick chains) are interwound with each other to form a duplex, whereas at 85 C they are separated from each other.

These ring vibrational modes [150,153,154] are shown in Fig. 6 (under “six-membered ring”). In the 1750–1650 cmÀ1 region, two strong infrared bands appear at 1738 and 1675 cmÀ1 (Fig. 33, lower trace). The former is a nearly pure C2¼O stretching, and the latter is an in-phase stretching of the C4¼O and C5¼C6 bonds. In the 1500–1400 cmÀ1 region, ab initio calculations predict two stronger bands due to the n6b ring vibration (see Fig. 5). The latter is expected to be shifted to a lower frequency on deuteration.

The P values corresponding to different deoxyribose ring conformations can be seen in Fig. 12. In this description, the E and T conformations alternate every 18 as one moves around the pseudorotation cycle. Real sugar rings need not fall within these discrete categories, but may exist at any energetically allowed P value. Thus, the conformation of every deoxyribose moiety in a DNA chain can be represented by an angle P. 8). Different DNA conformations actually have different energetic preferences for their sugar conformations arising from both environmental conditions and DNA sequence.

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