By Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)
The bicentenary of William Withering's now recognized clinical document entitled "An Account of the Foxglove and a few of its clinical makes use of" has given us the social gathering to research the cutting-edge. Cardiac glycosides in 1985 are thought of tobe the root for clinical therapy of myocardial failure, including diuretics and vasodilators within the extra serious situations. however, the talk as to their distinctive position within the remedy of center failure with sinus rhythm hasn't ever ceased. even though cardiac glycosides are of unquestionable worth in tachycardia brought on by atrial traumatic inflammation or atrial flutter, the power use of those medicinal drugs in sinus rhythm isn't really typically authorised. the advance of tolerance has been mentioned. it's of curiosity that Withering hirnself wrote: "-let it (foxglove) be persisted till it both acts at the kidneys, the tummy, the heart beat, or the bowels; Iet or not it's stopped upon the 1st visual appeal of any of those results, and that i will continue that the sufferer won't be afflicted by its exhibition, nor the practitioner be upset in any moderate expectation. " In West Germany by myself, greater than 3 million sufferers (about five% of the entire inhabitants) are continually taking cardiac glycosides. those medications are the main prescribed medicaments in lots of international locations. hence, we thought of it invaluable and essential to evaluation in a severe method trendy wisdom in regards to the foxglove; to file new findings and to judge previous Statements.
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Extra resources for Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance
Med-Hyg 43: 290-295 24. Stenius R (1916) Die Geschichte der Digitalis purpurea und ihre Bedeutung in der Medizin bis etwa zum Jahre 1870. Vet med Diss Dresden 1916 25. Stenius R (1918) Die neue Geschichte der Digitalis purpurea. Arch wiss prakt Tierheilkd 44: H 5-6 26. Weese H (1936) Die Geschichte der Digitalis purpurea und der Strophantusglykoside. In: Digitalis. Thieme Leipzig p 1 ff 27. Wirth H (1961) Der Rote Fingerhut und andere herzwirksame Heilpflanzen. Franckh'sche Verlagshandlung Stuttgart, Kosmos-Verlag p 106ff 28.
Lowry DH, Rosebrough NJ, Farr AL, Randall RG (1951) J Bio! Chem 193: 265-275 14. MacLennan DH, Brand! CJ, Korczak B, Green NM (1985) Nature 316: 696-700 15. O'Farrell PH (1975) J Bio! Chem 250: 4007-4021 16. Periyasamy SM, Huang W-H, Askari A (1983) Comp Bioehern Physiol76B: 449-454 17. Riordan JF, Vallee BL (1972) Meth Enzymol25: 515-521 18. Schneider JW, Mercer RW, Caplan M, Emanuel JR, Sweadner KJ, Benz EJ jr, Levenson R (1985) Proc Natl Acad Sei USA 82: 6357-6361 19. Schwartz A, Allen JC, Harigaya S (1969) J Pharm Exp Ther 168: 31-41 20.
An elevation of intracellular Ca 2+ is a signal for activation of cellular functions such as neurotransmitter release, secretion of endocrirre and exocrine glands, and contraction of cardiac, skeletal or vascular smooth muscle. A slight reduction in energy expenditure due to low sodium pump activity has been proposed to be the cause of obesity in several genetic models (8), and an increase in Na+ ,K +ATPase units has been suggested to increase the rate of ATP hydrolysis and to elevate basal metabolism in hyperthyroidism (9).