Download Biomechanics of the Gravid Human Uterus by Roustem N. Miftahof, Hong Gil Nam PDF

By Roustem N. Miftahof, Hong Gil Nam

The complexity of human uterine functionality and rules is without doubt one of the nice wonders of nature and represents a frightening problem to resolve. This publication is devoted to the biomechanical modeling of the gravid human uterus and provides an instance of the appliance of the mechanics of solids and the idea of sentimental shells to discover scientific difficulties of work and supply. After a quick assessment of the anatomy, body structure and biomechanics of the uterus, the authors concentration regularly on electromechanical wave tactics, their foundation, dynamics, and neuroendocrine and pharmacological modulations. within the final bankruptcy functions, pitfalls and difficulties on the topic of modeling and laptop simulations of the pregnant uterus and pelvic flooring buildings are mentioned. a suite of workouts is additional on the finish of every bankruptcy to assist readers with self-evaluation.

The publication serves as a useful resource of data for researchers, teachers and complicated undergraduate and graduate scholars attracted to structures biology, utilized arithmetic and biomedical engineering.

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Extra resources for Biomechanics of the Gravid Human Uterus

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It is of utmost importance though to establish receptor topography and their expression throughout the fundus to cervix, during gestation and labor. Ligand binding studies revealed heterogeneous ratios of EP1, EP3, and PGF2a receptors in the organ with the highest concentration in the fundus (Giannopoulos et al. 1985). The lower segment of the uterus at term has been demonstrated to respond more to relaxatory (EP2) rather than to excitatory (EP3) receptor activation (Brodt-Eppley and Myatt 1999).

72 mM. The myometrium undergoes tonic contraction, T a ¼ 23:75 mN/cm:. A concurrent electrical stimulation of the myofiber evokes ion currents of f s intensities: I~Ca ¼ 1:3; I~Ca ¼ 0:61; I~K1 ¼ 0:62; I~CaÀK ¼ 1:63; I~Cl ¼ 1:89ðnAÞ, and a transient production of a burst of high-frequency, n ¼ 6 Hz, action potentials of amplitude 53 mV. The fast T-type Ca2+ current  à provides the main influx ¼ 0:62 mM is recorded. of intracellular calcium during which max Ca2þ i The fasciculus generates the active force, T a ¼ 20:7 mN/cm.

The tissue was assumed to be homogenous, incompressible biocomposite and possessed exponentially elastic and viscoelastic properties. Deformations were small, but displacements were finite. The head was in the vertex 22 2 Models of the Gravid Uterus position and exerted dilatational constant pressure on the membrane. No friction condition was imposed between the head and the cervix. The axial load was defined a priori as a function of time. The four degrees-of-freedom linear element approximation was solved for deflection confined by sliding curved restraints.

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