Download Bioinformatics: Sequence, Structure and Databanks: A by Des Higgins, Willie Taylor PDF

By Des Higgins, Willie Taylor

This quantity covers functional very important issues within the research of protein sequences and buildings. It contains evaluating amino acid sequences to buildings evaluating buildings to one another, looking info on complete protein households in addition to looking with unmarried sequences, the best way to use the net and the way to establish and use the SRS molecular biology database administration method. eventually, there are chapters on a number of series alignment and protein secondary constitution prediction. This booklet may be worthy to occasional clients of those recommendations in addition to skilled execs or researchers.

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Additional info for Bioinformatics: Sequence, Structure and Databanks: A Practical Approach

Sample text

The major difficulty with non-identical objects, such as a pair of protein structures, is that they typically have different numbers of amino acids, different amino acids with different numbers, types and connectivities of atoms. Furthermore, amino acids present in one structure can be missing in the other: insertions and deletions—the gaps seen in a sequence alignment. Thus, except in the case of one protein co-ordinate set being compared with itself, no two proteins will have atoms in exactly identical positions.

Recognition of distantly related proteins through energy calculations. Proteins: Struct, Funct. , 19, 132. 5. , Johnson, M. , and Blundell, T. L (1992). Environment-specific amino-acid substitution tables—tertiary templates and prediction of protein folds. , 1, 216. 6. , and Nishikawa, K. (1995). Detection of protein 3-D-l-D compatability characterised by the evaluation of side-chain packing and electrostatic interactions. J. Biochem. (japan), 118, 137. 7. , and Bryant, S. H. (1995). Threading a database of protein cores.

1, 216. 6. , and Nishikawa, K. (1995). Detection of protein 3-D-l-D compatability characterised by the evaluation of side-chain packing and electrostatic interactions. J. Biochem. (japan), 118, 137. 7. , and Bryant, S. H. (1995). Threading a database of protein cores. Proteins, 23, 356. 8. Lathrop, R. H. and Smith, T. F. (1996). J. Mol. , 255, 641. 9. Taylor, W. R. (1997). J. , 269, 902. 10. Bowie, J. , and Eisenberg, D. (1991). A method to identify protein sequences that fold into a known three-dimensional structure.

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